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Dec 9, 2024 | 
nature.com | Paola Arlotta |Helen S. Bateup |J. Gray Camp |Silvia Cappello |Fred Gage |Jürgen A. Knoblich | +13 more
AbstractAs the field of neural organoids and assembloids rapidly expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility of these models.
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Dec 9, 2024 | 00409-0&sz=64)
cell.com | Meghan T. Logun |Xin Wang |Yusha Sun |Stephen J. Bagley |Nannan Li |Arati Desai | +9 more
Keywordsglioblastomapatient-derived tumor organoidex vivoCAR-T cell therapyreal-time correlativeclinical trialorganoidcytokineGet full text accessLog in, subscribe or purchase for full access. References1. Drost, J. ∙ Clevers, H. Organoids in cancer researchNat. Rev. Cancer. 2018; 18:407-4182. Jiang, X. ∙ Oyang, L. ∙ Peng, Q. ... Organoids: opportunities and challenges of cancer therapyFront. Cell Dev. Biol. 2023; 11, 12325283. Wang, X. ∙ Sun, Y. ∙ Zhang, D.Y. ...
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Nov 4, 2024 | 
nature.com | Huasheng Yu |Saad S. Nagi |Dmitry Usoskin |Yizhou Hu |Otmane Bouchatta |Hanying Yan | +10 more
AbstractThe versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG) neurons. However, soma transcriptomes of individual human (h)DRG neurons—critical information to decipher their functions—are lacking due to technical difficulties. In this study, we isolated somata from individual hDRG neurons and conducted deep RNA sequencing (RNA-seq) to detect, on average, over 9,000 unique genes per neuron, and we identified 16 neuronal types.
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Mar 13, 2024 | 
nature.com | Stephen J. Bagley |Meghan T. Logun |Julie K. Jadlowsky |Fang Chen |MacLean P. Nasrallah |Wei-Ting Hwang | +5 more
AbstractRecurrent glioblastoma (rGBM) remains a major unmet medical need, with a median overall survival of less than 1 year. Here we report the first six patients with rGBM treated in a phase 1 trial of intrathecally delivered bivalent chimeric antigen receptor (CAR) T cells targeting epidermal growth factor receptor (EGFR) and interleukin-13 receptor alpha 2 (IL13Rα2). The study’s primary endpoints were safety and determination of the maximum tolerated dose.
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Feb 26, 2024 | 
nature.com | Xufeng Xue |Richard O’Laughlin |Robin Yan |Yi Zheng |Yue Liu |Azim Surani | +5 more
AbstractHuman nervous system is arguably the most complex but highly organized organ. Foundation of its complexity and organization is laid down during regional patterning of neural tube (NT), the embryonic precursor to human nervous system. Historically, studies of NT patterning have relied on animal models to uncover underlying principles.
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Dec 19, 2023 | 
nature.com | Feng Zhang |Guo-li Ming
AbstractVarious chemical modifications of all RNA transcripts, or epitranscriptomics, have emerged as crucial regulators of RNA metabolism, attracting significant interest from both basic and clinical researchers due to their diverse functions in biological processes and immense clinical potential as highlighted by the recent profound success of RNA modifications in improving COVID-19 mRNA vaccines.
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Dec 15, 2023 | 00254-7&sz=64)
cell.com | Jonas Cerneckis |Guo-li Ming |Hongjun Song |Chuan He
HighlightsAdvanced detection of RNA modifications, especially N6-methyladenosine, paves the way for transcriptome-wide, single-cell, and stoichiometric modification profiling at single-nucleotide resolution. RNA modification databases, tumor atlases, drug-like compound libraries, and machine learning have accelerated therapeutic development focused on epitranscriptomics.
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Jul 28, 2023 | 
nature.com | Yi Zhou |Hongjun Song |Guo-li Ming
AbstractBrain development in humans is achieved through precise spatiotemporal genetic control, the mechanisms of which remain largely elusive. Recently, integration of technological advances in human stem cell-based modelling with genome editing has emerged as a powerful platform to establish causative links between genotypes and phenotypes directly in the human system.
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Jul 11, 2023 | 
nature.com | Carolina Gracia-Diaz |Qian Yang |Natalia Padilla |Elisa A. Waxman |Dong Li |Paul Mark | +14 more
AbstractGenetic variants in chromatin regulators are frequently found in neurodevelopmental disorders, but their effect in disease etiology is rarely determined. Here, we uncover and functionally define pathogenic variants in the chromatin modifier EZH1 as the cause of dominant and recessive neurodevelopmental disorders in 19 individuals. EZH1 encodes one of the two alternative histone H3 lysine 27 methyltransferases of the PRC2 complex.
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Mar 15, 2023 | 
nature.com | Hongjun Song |Guo-li Ming
Cite this articleCheng, Y., Song, H., Ming, Gl. et al. Epigenetic and epitranscriptomic regulation of axon regeneration. Mol Psychiatry (2023).
