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Jan 16, 2025 | 
nature.com | Hongjun Song
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Dec 9, 2024 | 
nature.com | Paola Arlotta |Helen S. Bateup |J. Gray Camp |Silvia Cappello |Fred Gage |Jürgen A. Knoblich | +13 more
AbstractAs the field of neural organoids and assembloids rapidly expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility of these models.
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Dec 9, 2024 | 00409-0&sz=64)
cell.com | Meghan T. Logun |Xin Wang |Yusha Sun |Stephen J. Bagley |Nannan Li |Arati Desai | +9 more
Keywordsglioblastomapatient-derived tumor organoidex vivoCAR-T cell therapyreal-time correlativeclinical trialorganoidcytokineGet full text accessLog in, subscribe or purchase for full access. References1. Drost, J. ∙ Clevers, H. Organoids in cancer researchNat. Rev. Cancer. 2018; 18:407-4182. Jiang, X. ∙ Oyang, L. ∙ Peng, Q. ... Organoids: opportunities and challenges of cancer therapyFront. Cell Dev. Biol. 2023; 11, 12325283. Wang, X. ∙ Sun, Y. ∙ Zhang, D.Y. ...
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Nov 28, 2024 | 
nature.com | Yuanqi Wang |Zhixuan Feng |Hongjun Song
AbstractThe Arctic Ocean has experienced significant sea ice loss over recent decades, shifting towards a thinner and more mobile seasonal ice regime. However, the impacts of these transformations on the upper ocean dynamics of the biologically productive Pacific Arctic continental shelves remain underexplored.
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Nov 4, 2024 | 
nature.com | Huasheng Yu |Saad S. Nagi |Dmitry Usoskin |Yizhou Hu |Otmane Bouchatta |Hanying Yan | +10 more
AbstractThe versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG) neurons. However, soma transcriptomes of individual human (h)DRG neurons—critical information to decipher their functions—are lacking due to technical difficulties. In this study, we isolated somata from individual hDRG neurons and conducted deep RNA sequencing (RNA-seq) to detect, on average, over 9,000 unique genes per neuron, and we identified 16 neuronal types.
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Jun 5, 2024 | 
mdpi.com | Xin Gao |Yunlei Zhang |Hongjun Song |Ying Li
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
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May 23, 2024 | 
mdpi.com | Xiaoyang Wang |Fan Li |Fei Shao |Hongjun Song
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
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Mar 13, 2024 | 
nature.com | Stephen J. Bagley |Meghan T. Logun |Julie K. Jadlowsky |Fang Chen |MacLean P. Nasrallah |Wei-Ting Hwang | +5 more
AbstractRecurrent glioblastoma (rGBM) remains a major unmet medical need, with a median overall survival of less than 1 year. Here we report the first six patients with rGBM treated in a phase 1 trial of intrathecally delivered bivalent chimeric antigen receptor (CAR) T cells targeting epidermal growth factor receptor (EGFR) and interleukin-13 receptor alpha 2 (IL13Rα2). The study’s primary endpoints were safety and determination of the maximum tolerated dose.
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Feb 26, 2024 | 
nature.com | Xufeng Xue |Richard O’Laughlin |Robin Yan |Yi Zheng |Yue Liu |Azim Surani | +5 more
AbstractHuman nervous system is arguably the most complex but highly organized organ. Foundation of its complexity and organization is laid down during regional patterning of neural tube (NT), the embryonic precursor to human nervous system. Historically, studies of NT patterning have relied on animal models to uncover underlying principles.
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Jan 7, 2024 | 
mdpi.com | Bingji Chen |Fengli Xue |Hongjun Song
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
