Jonas Meisner

1 month ago | cell.com | Kirstine Ravn |Jonas Meisner |Lasse Danielsen |Michael Eriksen Benros |Thorfinn Sand Korneliussen |Martin Sikora | +6 more

Keywords CCR5 CCR5delta32 HIV-1 infection resistance pleiotropy haplotype recombination ancient genomes evolution positive selection immune genes Introduction Humans have been exposed to pathogens over the course of our evolutionary history, and adaptations to them have left numerous signatures in our genomes.1,2,3 In recent years, evidence for selection has been found in genes involved in the development of tolerance against intracellular pathogens and in the inflammatory response against...

May 1, 2024 | medrxiv.org | Jonas Meisner |Michael Eriksen Benros |Simon Rasmussen

The authors have declared no competing interest. Lundbeck Foundation (R380-2021-1225 and R278-2018-1411) and the Novo Nordisk Foundation (NNF14CC0001 and NNF23SA0084103). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.