Thorfinn Sand Korneliussen

Apr 9, 2024 | biorxiv.org | Isin Altinkaya |Rasmus Nielsen |Thorfinn Sand Korneliussen

AbstractMotivation: Accurate quantification of genotype uncertainty is pivotal in ensuring the reliability of genetic inferences drawn from NGS data. Genotype uncertainty is typically modeled using Genotype Likelihoods (GLs), which can help propagate measures of statistical uncertainty in base calls to downstream analyses.

Jan 10, 2024 | nature.com | Evan K. Irving-Pease |Anders Fischer |Karl-Göran Sjögren |Alma Halgren |Ruairidh Macleod |Rasmus Henriksen | +14 more

AbstractThe Holocene (beginning around 12,000 years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for the dietary, physical and mental health of present-day populations. Using a dataset of more than 1,600 imputed ancient genomes1, we modelled the selection landscape during the transition from hunting and gathering, to farming and pastoralism across West Eurasia.

Jan 10, 2024 | nature.com | Yaoling Yang |Evan K. Irving-Pease |Kathrine E. Attfield |Gabriele Scorrano |Thorfinn Sand Korneliussen |Martin Sikora | +3 more

AbstractMultiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when, where and how this genetic risk originated1.