Kirstine Ravn

1 month ago | cell.com | Kirstine Ravn |Jonas Meisner |Lasse Danielsen |Michael Eriksen Benros |Thorfinn Sand Korneliussen |Martin Sikora | +6 more

Keywords CCR5 CCR5delta32 HIV-1 infection resistance pleiotropy haplotype recombination ancient genomes evolution positive selection immune genes Introduction Humans have been exposed to pathogens over the course of our evolutionary history, and adaptations to them have left numerous signatures in our genomes.1,2,3 In recent years, evidence for selection has been found in genes involved in the development of tolerance against intracellular pathogens and in the inflammatory response against...