Jonathan Grinstein

San Diego

North American Editor at Inside Precision Medicine

Scientist turned storyteller. North American Editor @inside_pm. for story leads: [email protected]

Articles

Colorectal Cancer Stages Tied to Microbiome, May Improve Non-invasive Tests

3 days ago | insideprecisionmedicine.com | Jonathan Grinstein

Researchers have uncovered the potential role of gut microbes in the early detection and monitoring of colorectal cancer (CRC) in a groundbreaking international study. By analyzing stool samples from over 3,700 individuals across 18 international cohorts, the study mapped microbial changes associated with cancer stages, tumor location, and progression, refining our understanding of the microbiome as a diagnostic and prognostic tool for one of the deadliest cancers worldwide.
First Personalized CRISPR Gene Editing Therapy Patient Baby KJ Discharged

4 days ago | insideprecisionmedicine.com | Jonathan Grinstein

On Tuesday, 307 days after he was first admitted to Children’s Hospital of Philadelphia (CHOP), KJ Muldoon went home after being successfully treated with the first personalized CRISPR gene editing therapy. KJ, who has a serious and rare genetic condition called severe carbamoyl phosphate synthetase 1 (CPS1), received two doses of a base editor bound to a bespoke targeting guide sequence using lipid nanoparticles (LNPs) when he was 7 and 8 months old.
First AI Platform for Breast Cancer Risk Prediction Approved By FDA

5 days ago | insideprecisionmedicine.com | Jonathan Grinstein

Throughout her career as a radiologist, Connie Lehman, MD, dedicated herself to the early detection of breast cancer. However, she came to the realization that there were limited imaging tools available for assessing the risk of breast cancer, and those that were there were heavily outdated.
Pan-Cancer Proteome Atlas Catalogs 999 Primary Tumors, Available Worldwide

1 week ago | insideprecisionmedicine.com | Jonathan Grinstein

Pick a cancer that you’d like to investigate. There’s a good chance that you can now pull up that cancer’s proteome. And if you can’t, researchers have made major inroads that are paving the way for proteomic maps for more than 200 described cancers. An international collaboration of four cancer proteomics laboratories and their clinical partners released The Pan-Cancer Proteome Atlas (TPCPA), the most comprehensive tumor protein map to date.
PSA on PRS: Population Genomic Screens Need More Than Pathogenic Variants

1 week ago | insideprecisionmedicine.com | Jonathan Grinstein

Jonathan D. Grinstein, PhD, the North American Editor of Inside Precision Medicine, hosts a new series called Behind the Breakthroughs that features the people shaping the future of medicine. With each episode, Jonathan gives listeners access to their motivational tales and visions for this emerging, game-changing field.
For Type 2 Diabetes, Phosphoproteomics Opens Personalized Treatment

1 week ago | insideprecisionmedicine.com | Jonathan Grinstein

Nearly 500 million people have type 2 diabetes (T2D) worldwide, yet the ability to dissect the highly heterogeneous disease progression of each individual at a molecular level has limited the implementation of precision medicine approaches.
Antimalarials Absorbed By Mosquito Feet Kill Parasite, Halt Transmission

2 weeks ago | insideprecisionmedicine.com | Jonathan Grinstein

After years of steady progress, the battle against malaria is facing a daunting resurgence. Once in decline, malaria deaths have plateaued, largely due to the growing resistance of Anopheles mosquitoes to the insecticides embedded in long-lasting insecticide-treated nets (LLINs)—a cornerstone of prevention efforts. This alarming trend underscores an urgent need for innovation to outpace the adaptive strategies of both vector and parasite.
Alzheimer’s Early Detection Gets New Leads With Plasma Proteomics

2 weeks ago | insideprecisionmedicine.com | Jonathan Grinstein

The discovery of plasma proteins linked to Alzheimer’s disease has created opportunities for early diagnosis and customized treatment strategies. Researchers at Washington University School of Medicine in St. Louis identified a set of 7 biomarkers that predict early Alzheimer’s disease using machine learning on findings from an extensive plasma proteomics study.
Non-Opioid Compound Shows Acute and Chronic Pain Relief Potential

2 weeks ago | insideprecisionmedicine.com | Jonathan Grinstein

Researchers have created a novel non-opioid chemical called SBI-810 that exhibits potent analgesic effects in animal studies without the negative side effects or addiction linked to opioids. What sets SBI-810 apart is the chemical’s dual impact on both the central and peripheral nervous systems, effectively reducing pain while minimizing the risk of opioid-induced complications such as addiction, constipation, and withdrawal symptoms.
Oral Norovirus Vaccine Generates Immunity, Reduces Viral Shedding in Phase II

3 weeks ago | insideprecisionmedicine.com | Jonathan Grinstein

Often dubbed the “perfect pathogen,” norovirus is a highly contagious virus responsible for acute gastroenteritis (AGE) outbreaks worldwide. It spreads through contaminated food, water, person-to-person contact, and even aerosolized particles. For vulnerable populations like children and older adults, infections frequently require hospitalization and intravenous rehydration. Despite its significant public health impact, an effective vaccine has long remained out of reach.