Joon-Yong An

Oct 10, 2024 | science.org | Dimitri Fabrèges |Stephanie Hampton |Joon-Yong An |Yujin Kim

PerspectiveNeurodevelopmentSomatic noncoding mutations likely contribute to schizophrenia developmentJoon-Yong An and Yujin KimAuthors Info & AffiliationsAbstractHuman germline mutations—genetic changes in an egg or sperm—are inherited, present in every cell, and play roles in early development (1), whereas somatic mutations arise postzygotically and may or may not affect developmental trajectories.

Nov 12, 2023 | nature.com | Ryan Friedman |Simona Sarafinovska |Joon-Yong An |Stephan Sanders |Barak A. Cohen

AbstractThe function of regulatory elements is highly dependent on the cellular context, and thus for understanding the function of elements associated with psychiatric diseases these would ideally be studied in neurons in a living brain. Massively Parallel Reporter Assays (MPRAs) are molecular genetic tools that enable functional screening of hundreds of predefined sequences in a single experiment.