Simona Sarafinovska

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Single-Cell Resolution of Individual Variation in Hypothalamic Neurons Allows Targeted Manipulation Affecting Social Motivation

1 month ago | biorxiv.org | Simona Sarafinovska |Sarah K Koester |Lisa Z. Fang |Joshua Thorpe

AbstractDespite decades of research, connecting molecular and cellular phenotypes to complex behavioral traits remains an elusive goal1. Social motivation exhibits individual trait variation2, which we hypothesize is mediated by molecular and cellular variability across hypothalamic neurons.
A Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of non-coding elements in vivo - Communications Biology

Nov 12, 2023 | nature.com | Ryan Friedman |Simona Sarafinovska |Joon-Yong An |Stephan Sanders |Barak A. Cohen

AbstractThe function of regulatory elements is highly dependent on the cellular context, and thus for understanding the function of elements associated with psychiatric diseases these would ideally be studied in neurons in a living brain. Massively Parallel Reporter Assays (MPRAs) are molecular genetic tools that enable functional screening of hundreds of predefined sequences in a single experiment.

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