Jörg Hanrieder

Sep 11, 2024 | pubs.acs.org | Yuanmo Wang |Ajay Pradhan |Pankaj Gupta |Jörg Hanrieder

Neuronal communication occurs through the rapid, calcium-triggered release of neurotransmitters from synaptic vesicles fusing with the cell plasma membrane. (1) This process, known as exocytosis, happens in less than a millisecond, (2) allowing neurotransmitters released to bind to receptors at neighboring neurons and transmit chemical signals.

Mar 22, 2024 | nature.com | Fernando Gonzalez-Ortiz |Maciej Dulewicz |Vijay R. Varma |Tammaryn Lashley |Gunnar Brinkmalm |Susan M. Resnick | +6 more

AbstractBlood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer’s disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize tau forms phosphorylated additionally at threonine-212, but the contribution of p-tau212 alone to AD is unknown. We developed a blood-based immunoassay that is specific to p-tau212 without cross-reactivity to p-tau217. Here, we examined the diagnostic utility of plasma p-tau212.

Feb 19, 2024 | onlinelibrary.wiley.com | Jörg Hanrieder

AD Alzheimer's disease A ‘beta’ beta-amyloid ApoE apolipoprotein E APP amyloid precursor protein ABCA7 ATP-binding cassette sub-family A member 7 BMP Bis(monoacylglycero)phosphate cPLA2 cytosolic phospholipases A2 DESI desorption electrospray ionization IHC immunohistochemistry LPA lysophosphatidic acid LPC lysophosphatidyl choline LPE lysophosphatidyl ethanolamine MALDI matrix assisted laser desorption/ionization MSI mass spectrometry imaging PC phosphatidylcholine PG phosphatidylglycerol...