Joseph Loscalzo

Oct 24, 2024 | nature.com | Yunguang Qiu |Mateo Torres |Weiqiang Lu |Siqi Liang |Charis Eng |Joseph Loscalzo | +1 more

AbstractTo assist the translation of genetic findings to disease pathobiology and therapeutics discovery, we present an ensemble deep learning framework, termed PIONEER (Protein–protein InteractiOn iNtErfacE pRediction), that predicts protein-binding partner-specific interfaces for all known protein interactions in humans and seven other common model organisms to generate comprehensive structurally informed protein interactomes.

Feb 15, 2024 | jci.org | Joseph Loscalzo

100th Anniversary ViewpointOpen Access | 10.1172/JCI176747 Published inVolume 134, Issue 4onFebruary 15, 2024J Clin Invest. 2024;134(4):e176747. https://doi.org/10.1172/JCI176747. © 2024 LoscalzoThis work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.