Charis Eng

Jan 17, 2025 | biorxiv.org | Alejandra Fernandez |Alejandra Fernández |Nick Sarn |Charis Eng |Kevin Wright

AbstractAutism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social interactions, repetitive behaviors, and hyper- or hyposensitivity to sensory stimuli. The mechanisms underlying the emergence of sensory features in ASD are not fully understood, but recent studies in rodent models highlight that these may result from differences in primary sensory neurons themselves.

Nov 22, 2024 | erc.bioscientifica.com | Frederic Castinetti |Charis Eng

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Oct 24, 2024 | nature.com | Yunguang Qiu |Mateo Torres |Weiqiang Lu |Siqi Liang |Charis Eng |Joseph Loscalzo | +1 more

AbstractTo assist the translation of genetic findings to disease pathobiology and therapeutics discovery, we present an ensemble deep learning framework, termed PIONEER (Protein–protein InteractiOn iNtErfacE pRediction), that predicts protein-binding partner-specific interfaces for all known protein interactions in humans and seven other common model organisms to generate comprehensive structurally informed protein interactomes.

Jul 1, 2024 | onlinelibrary.wiley.com | Melad N Dababneh |Laura Rabinowitz |Charis Eng |Gilman Plitt

FND follicular nodular disease FTC follicular thyroid carcinoma IEFVPTC invasive encapsulated/well-demarcated follicular variant papillary thyroid carcinoma IHC immunohistochemistry NIFTP noninvasive follicular thyroid neoplasm with papillary-like nuclear features PHTS PTEN hamartoma tumour syndrome PTC papillary thyroid carcinoma PTEN Phosphatase and tensin homologue THiPS Thyroid histomorphologic PHTS score WHO World Health Organization Introduction Pathogenic germline mutations in the...

Jan 8, 2024 | nature.com | Charis Eng

AbstractImmunotherapy, specifically immune checkpoint blockade (ICB), has revolutionized the treatment paradigm of triple-negative breast cancers (TNBCs). However, a subset of TNBCs devoid of tumor-infiltrating T cells (TILs) or PD-L1 expression generally has a poor response to immunotherapy. In this study, we aimed to sensitize TNBCs to ICB by harnessing the immunomodulating potential of S. aureus, a breast-resident bacterium. We show that intratumoral injection of spent culture media from S.