Weiqiang Lu

Oct 24, 2024 | nature.com | Yunguang Qiu |Mateo Torres |Weiqiang Lu |Siqi Liang |Charis Eng |Joseph Loscalzo | +1 more

AbstractTo assist the translation of genetic findings to disease pathobiology and therapeutics discovery, we present an ensemble deep learning framework, termed PIONEER (Protein–protein InteractiOn iNtErfacE pRediction), that predicts protein-binding partner-specific interfaces for all known protein interactions in humans and seven other common model organisms to generate comprehensive structurally informed protein interactomes.