Joseph Powell

Sep 26, 2024 | nature.com | Saori Sakaue |Aparna Nathan |Joseph Powell |Po-Ru Loh

AbstractDisease risk alleles influence the composition of cells present in the body, but modeling genetic effects on the cell states revealed by single-cell profiling is difficult because variant-associated states may reflect diverse combinations of the profiled cell features that are challenging to predefine. We introduce Genotype–Neighborhood Associations (GeNA), a statistical tool to identify cell-state abundance quantitative trait loci (csaQTLs) in high-dimensional single-cell datasets.

Jul 23, 2024 | yahoo.com | Joseph Powell

Joseph Powell, Cincinnati EnquirerJuly 23, 2024 at 3:57 PM·3 min readJack Greiner, partner of Faruki PLLA disgruntled Massachusetts parent recently obtained an important ruling from the U. S. Court of Appeals for the First Circuit. The Gloucester school his daughter attended may now face liability for threats it made. Inge Berge is a citizen journalist who lives in Gloucester, Massachusetts. In early March 2022, he went to the city's school superintendent's office — which is open to the public.

Dec 8, 2023 | ca.sports.yahoo.com | Joseph Powell

The sudden and untimely passing of Benjamin Zephaniah at age 65 has rightly brought reflection on his legacy as a poet and as a writer, the two fields in which he made monumental contributions. Zephaniah’s warmth, his accessibility –- and his lyrical genius – made him a household name and a national treasure. Hear him, in 2018, on BBC Radio 3, waxing lyrical about his favourite Shakespearean moments.

Nov 29, 2023 | nature.com | Aparna Nathan |fan zhang |Anna Jonsson |Karthik A. Jagadeesh |Kushal Dey |Joseph Powell | +4 more

AbstractThe human leukocyte antigen (HLA) locus plays a critical role in complex traits spanning autoimmune and infectious diseases, transplantation and cancer. While coding variation in HLA genes has been extensively documented, regulatory genetic variation modulating HLA expression levels has not been comprehensively investigated. Here we mapped expression quantitative trait loci (eQTLs) for classical HLA genes across 1,073 individuals and 1,131,414 single cells from three tissues.

Jun 14, 2023 | dermatologyrepublic.com.au | Joseph Powell

A fundamental shift in science will bring about a fundamental shift in healthcare, says Garvan Institute’s Professor Joseph Powell. The human body is made up of 30 trillion cells, each of which contributes to health and disease in a unique way. Current clinical testing masks this variety by using “bulk” techniques that generate data as an average signal over millions of cells.