Kushal Dey

Apr 9, 2024 | nature.com | Saori Sakaue |Kushal Dey |Karthik A. Jagadeesh |Masahiro Kanai |Michael Brenner |Alkes L Price | +1 more

AbstractTranslating genome-wide association study (GWAS) loci into causal variants and genes requires accurate cell-type-specific enhancer–gene maps from disease-relevant tissues. Building enhancer–gene maps is essential but challenging with current experimental methods in primary human tissues.

Nov 29, 2023 | nature.com | Aparna Nathan |fan zhang |Anna Jonsson |Karthik A. Jagadeesh |Kushal Dey |Joseph Powell | +4 more

AbstractThe human leukocyte antigen (HLA) locus plays a critical role in complex traits spanning autoimmune and infectious diseases, transplantation and cancer. While coding variation in HLA genes has been extensively documented, regulatory genetic variation modulating HLA expression levels has not been comprehensively investigated. Here we mapped expression quantitative trait loci (eQTLs) for classical HLA genes across 1,073 individuals and 1,131,414 single cells from three tissues.