Marylyn D. Ritchie

Nov 28, 2024 | biorxiv.org | Rachit Kumar |Joseph Romano |Marylyn D. Ritchie

AbstractAccurately determining the binding affinity of a ligand with a protein is important for drug design, development, and screening. With the advent of accessible protein structure prediction methods such as AlphaFold, several approaches have been developed that make use of information determined from the 3D structure for a variety of downstream tasks.

Nov 25, 2024 | mdpi.com | Anni Moore |Marylyn D. Ritchie

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Mar 22, 2024 | nature.com | Junhao Wen |Bingxin Zhao |Guray Erus |Elizabeth Mamourian |Gyujoon Hwang |Jingxuan Bao | +5 more

AbstractThe complex biological mechanisms underlying human brain aging remain incompletely understood. This study investigated the genetic architecture of three brain age gaps (BAG) derived from gray matter volume (GM-BAG), white matter microstructure (WM-BAG), and functional connectivity (FC-BAG). We identified sixteen genomic loci that reached genome-wide significance (P-value < 5×10−8).

Oct 16, 2023 | nature.com | Tanmoy Roychowdhury |Derek Klarin |Michael Levin |Joshua M. Spin |Colwyn A. Headley |Noah Tsao | +44 more

AbstractAbdominal aortic aneurysm (AAA) is a common disease with substantial heritability. In this study, we performed a genome-wide association meta-analysis from 14 discovery cohorts and uncovered 141 independent associations, including 97 previously unreported loci. A polygenic risk score derived from meta-analysis explained AAA risk beyond clinical risk factors.

May 5, 2023 | nature.com | Dominic B. Dwyer |Alessandro Pigoni |Junhao Wen |Gyujoon Hwang |Guray Erus |René S. Kahn | +11 more

AbstractUsing machine learning, we recently decomposed the neuroanatomical heterogeneity of established schizophrenia to discover two volumetric subgroups—a ‘lower brain volume’ subgroup (SG1) and an ‘higher striatal volume’ subgroup (SG2) with otherwise normal brain structure.