Joshua J. Ziarek

May 16, 2024 | onlinelibrary.wiley.com | James B. Bower |Scott A. Robson |Joshua J. Ziarek

1 INTRODUCTION G protein-coupled receptors (GPCRs) comprise the largest protein family in eukaryotes—accounting for 3–4% of the human genome (Fredriksson et al., 2003). With over a third of FDA-approved drugs targeting GPCRs, it follows that these receptors possess considerable significance in human physiology and pathology (Hauser et al., 2017).

Feb 2, 2024 | biorxiv.org | James B. Bower |Scott Robson |Joshua J. Ziarek

AbstractG-protein coupled receptors (GPCRs) are the largest class of membrane proteins in the human genome with high pharmaceutical relevance and implications to human health. These receptors share a prevalent architecture of seven transmembrane helices followed by an intracellular, amphipathic helix 8 (H8) and a disordered C-terminus.