James B. Bower

May 16, 2024 | onlinelibrary.wiley.com | James B. Bower |Scott A. Robson |Joshua J. Ziarek

1 INTRODUCTION G protein-coupled receptors (GPCRs) comprise the largest protein family in eukaryotes—accounting for 3–4% of the human genome (Fredriksson et al., 2003). With over a third of FDA-approved drugs targeting GPCRs, it follows that these receptors possess considerable significance in human physiology and pathology (Hauser et al., 2017).

Apr 6, 2024 | wbkr.com | Dan Field |James B. Bower |Brandon Nelson |Lorraine Mathews

Before the building upgrade at our sister station WBKR, there was a small TV in the studio. Every day, my buddy Dave Spencer would turn it on to Jeopardy and would play along in between talk breaks. If you are playing Trivial Pursuit, and have the opportunity to be Dave's partner, you should jump at the chance. A couple of years ago, he wrote an article about the times Owensboro, KY was mentioned on Jeopardy. So, when I saw this pop up on my Facebook news feed, I automatically thought about Spence.

Apr 2, 2024 | 1061evansville.com | Dan Field |James B. Bower |Brandon Nelson |Lorraine Mathews

Before the building upgrade at our sister station WBKR, there was a small TV in the studio. Every day, my buddy Dave Spencer would turn it on to Jeopardy and would play along in between talk breaks. If you are playing Trivial Pursuit, and have the opportunity to be Dave's partner, you should jump at the chance. A couple of years ago, he wrote an article about the times Owensboro, KY was mentioned on Jeopardy. So, when I saw this pop up on my Facebook news feed, I automatically thought about Spence.

Feb 2, 2024 | biorxiv.org | James B. Bower |Scott Robson |Joshua J. Ziarek

AbstractG-protein coupled receptors (GPCRs) are the largest class of membrane proteins in the human genome with high pharmaceutical relevance and implications to human health. These receptors share a prevalent architecture of seven transmembrane helices followed by an intracellular, amphipathic helix 8 (H8) and a disordered C-terminus.

Jun 7, 2023 | nature.com | Asuka Inoue |Miquel Pons |Scott A. Robson |Daniel Scott |Paul Gooley |Fabian Bumbak | +1 more

AbstractThe neurotensin receptor 1 (NTS1) is a G protein-coupled receptor (GPCR) with promise as a drug target for the treatment of pain, schizophrenia, obesity, addiction, and various cancers. A detailed picture of the NTS1 structural landscape has been established by X-ray crystallography and cryo-EM and yet, the molecular determinants for why a receptor couples to G protein versus arrestin transducers remain poorly defined.