Ju Heon Maeng

Sep 2, 2024 | nature.com | H. Jang |Nakul M. Shah |Ju Heon Maeng |Yonghao Liang |Noah L. Basri |Jiaxin Ge | +3 more

AbstractInhibiting epigenetic modulators can transcriptionally reactivate transposable elements (TEs). These TE transcripts often generate unique peptides that can serve as immunogenic antigens for immunotherapy. Here, we ask whether TEs activated by epigenetic therapy could appreciably increase the antigen repertoire in glioblastoma, an aggressive brain cancer with low mutation and neoantigen burden.