
Nakul M. Shah
Articles
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Sep 2, 2024 |
nature.com | H. Jang |Nakul M. Shah |Ju Heon Maeng |Yonghao Liang |Noah L. Basri |Jiaxin Ge | +3 more
AbstractInhibiting epigenetic modulators can transcriptionally reactivate transposable elements (TEs). These TE transcripts often generate unique peptides that can serve as immunogenic antigens for immunotherapy. Here, we ask whether TEs activated by epigenetic therapy could appreciably increase the antigen repertoire in glioblastoma, an aggressive brain cancer with low mutation and neoantigen burden.
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Jan 16, 2024 |
nature.com | Yonghao Liang |Nakul M. Shah
AbstractTransposable elements (TEs) represent almost half of the human genome. Historically deemed ‘junk DNA’, recent technological advancements have stimulated a wave of research into the functional impact of TEs on gene-regulatory networks in evolution and development, as well as in diseases including cancer. The genetic and epigenetic evolution of cancer involves the exploitation of TEs, whereby TEs contribute directly to cancer-specific gene activities.
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