Yonghao Liang

Sep 2, 2024 | nature.com | H. Jang |Nakul M. Shah |Ju Heon Maeng |Yonghao Liang |Noah L. Basri |Jiaxin Ge | +3 more

AbstractInhibiting epigenetic modulators can transcriptionally reactivate transposable elements (TEs). These TE transcripts often generate unique peptides that can serve as immunogenic antigens for immunotherapy. Here, we ask whether TEs activated by epigenetic therapy could appreciably increase the antigen repertoire in glioblastoma, an aggressive brain cancer with low mutation and neoantigen burden.

Jul 4, 2024 | nature.com | Yonghao Liang |Ting Wang

The impact of transposable elements (TEs) on gene regulatory networks and how they are governed remain poorly understood. A new study identifies a role for LINE1, a specific subset of TEs, in the long-range regulation of gene expression, particularly during embryonic development.

Jan 16, 2024 | nature.com | Yonghao Liang |Nakul M. Shah

AbstractTransposable elements (TEs) represent almost half of the human genome. Historically deemed ‘junk DNA’, recent technological advancements have stimulated a wave of research into the functional impact of TEs on gene-regulatory networks in evolution and development, as well as in diseases including cancer. The genetic and epigenetic evolution of cancer involves the exploitation of TEs, whereby TEs contribute directly to cancer-specific gene activities.