Judith Breuer

Jun 17, 2024 | nature.com | Kaylee B. Worlock |Masahiro Yoshida |Krzysztof Polanski |Liam Bolt |Laura Richardson |Machaela Palor | +13 more

Correction to: Nature Microbiology https://doi.org/10.1038/s41564-024-01658-1, published online 15 April 2024In the version of the article initially published, Paolo De Coppi’s surname originally appeared as “DeCoppi”. In the third paragraph of the article, the callout to Extended Data Fig. 3i has been amended from Extended Data Fig. 4i. In the legend to Fig. 6, the description of panel m (“Summary figure highlighting the key findings from the study.

Apr 14, 2024 | nature.com | Kaylee B. Worlock |Masahiro Yoshida |Krzysztof Polanski |Liam Bolt |Laura Richardson |Machaela Palor | +13 more

AbstractChildren infected with SARS-CoV-2 rarely progress to respiratory failure. However, the risk of mortality in infected people over 85 years of age remains high. Here we investigate differences in the cellular landscape and function of paediatric (<12 years), adult (30–50 years) and older adult (>70 years) ex vivo cultured nasal epithelial cells in response to infection with SARS-CoV-2.

Feb 23, 2024 | nature.com | Joseph F Standing |Laura Buggiotti |Claire Smith |Theo Sanderson |Fiona Ashford |Adrian Shields | +13 more

AbstractViral clearance, antibody response and the mutagenic effect of molnupiravir has not been elucidated in at-risk populations. Non-hospitalised participants within 5 days of SARS-CoV-2 symptoms randomised to receive molnupiravir (n = 253) or Usual Care (n = 324) were recruited to study viral and antibody dynamics and the effect of molnupiravir on viral whole genome sequence from 1437 viral genomes. Molnupiravir accelerates viral load decline, but virus is detectable by Day 5 in most cases.

Jan 16, 2024 | movementdisorders.onlinelibrary.wiley.com | Rimona S. Weil |Judith Breuer |Louis Tunnicliffe

The global burden of Parkinson's disease (PD) is rising rapidly with population growth and aging.1 Neurodegeneration in PD, which is characterized by α-synuclein aggregates (Lewy bodies) leading to the loss of midbrain dopaminergic neurons, may occur decades before clinical PD diagnosis.2 Its complex etiology remains poorly understood.