Louis Tunnicliffe

Apr 24, 2024 | bmjopen.bmj.com | Louis Tunnicliffe |Rutendo Muzambi |Jonathan Bartlett |Laura D Howe

ObjectivesThis systematic review aims to comprehensively summarise all existing literature on the association between infections (by type, site, severity) and telomere length or attrition across a broad range of study designs (see eligibility criteria) in adult humans. We aim to establish whether there is an association between infection and telomere length to inform future studies. Is there an association between infections and telomere length or attrition?

Jan 25, 2024 | drc.bmj.com | William Doran |Louis Tunnicliffe |Rutendo Muzambi |Christopher T. Rentsch

RESEARCH DESIGN AND METHODSCPRD Gold includes longitudinal primary care records from practices using Vision software covering a large, unselected study population, which is demographically representative of the UK.13 It contains details of symptoms, coded diagnoses, test results, referrals and drug prescriptions.

Jan 16, 2024 | movementdisorders.onlinelibrary.wiley.com | Rimona S. Weil |Judith Breuer |Louis Tunnicliffe

The global burden of Parkinson's disease (PD) is rising rapidly with population growth and aging.1 Neurodegeneration in PD, which is characterized by α-synuclein aggregates (Lewy bodies) leading to the loss of midbrain dopaminergic neurons, may occur decades before clinical PD diagnosis.2 Its complex etiology remains poorly understood.