Julián Candia

Oct 17, 2024 | nature.com | Michel Bernier |Nathan Price |Julián Candia |Yi-Han Hu |Andrew G. Deighan |Stephanie Dickinson | +6 more

AbstractBiological clocks and other molecular biomarkers of aging are difficult to implement widely in a clinical setting. In this study, we used routinely collected hematological markers to develop an aging clock to predict blood age and determine whether the difference between predicted age and chronologic age (aging gap) is associated with advanced aging in mice. Data from 2,562 mice of both sexes and three strains were drawn from two longitudinal studies of aging.

Sep 21, 2024 | biorxiv.org | Julián Candia |Giovanna Fantoni |Ruin Moaddel |Francheska Delgado-Peraza

AbstractSomaScan and Olink are the leading aptamer- and antibody-based platforms in current proteomics research, each of them capable of measuring thousands of human proteins with a broad range of endogenous concentrations. In this study, we investigated the effects of in vitro hemolysis and repeated freeze-thaw cycles in protein abundance quantification across 10,776 (11K SomaScan) and 1,472 (Olink Explore 1536) analytes, respectively.

Aug 13, 2024 | nature.com | Michael Duggan |Pyry N Sipilä |Joni V Lindbohm |Yifei Lu |Christos Davatzikos |Guray Erus | +7 more

AbstractInfections have been associated with the incidence of Alzheimer disease and related dementias, but the mechanisms responsible for these associations remain unclear. Using a multicohort approach, we found that influenza, viral, respiratory, and skin and subcutaneous infections were associated with increased long-term dementia risk. These infections were also associated with region-specific brain volume loss, most commonly in the temporal lobe.

Apr 10, 2024 | biorxiv.org | Julián Candia |Luigi Ferrucci

AbstractPathway enrichment analysis is an ubiquitous computational biology method to interpret a list of genes (typically derived from the association of large-scale omics data with phenotypes of interest) in terms of higher-level, predefined gene sets that share biological function, chromosomal location, or other common features. Among many tools developed so far, Gene Set Enrichment Analysis (GSEA) stands out as one of the pioneering and most widely used methods.

Mar 28, 2024 | nature.com | Eric V. Slud |Julián Candia |Xiaolin Wu |Jittiporn Chaisaingmongkol |Mathuros Ruchirawat |Zeynep Kacar | +1 more

AbstractHepatocellular carcinoma (HCC) is a molecularly heterogeneous solid malignancy, and its fitness may be shaped by how its tumor cells evolve. However, ability to monitor tumor cell evolution is hampered by the presence of numerous passenger mutations that do not provide any biological consequences.