Julian M Carosi

Dec 9, 2024 | biorxiv.org | Linh Dang |Alexis Martin |Julian M Carosi |Jemima R Gore

AbstractAutophagy is a naturally conserved mechanism crucial for degrading and recycling damaged organelles and proteins to support cell survival. This process slows biological ageing and age-related disease in preclinical models. However, there has been little translation of autophagy to the clinic, and we have identified a lack of measurement tools for physiological human autophagy as a barrier.

Sep 11, 2024 | biorxiv.org | Alexis Martin |Sofia Hassiotis |Julian M Carosi |Leanne K Hein

AbstractAutophagy is a waste-disposal pathway that protects against age-related pathology. It is widely accepted that autophagy declines with age, yet role that sex and diet-related obesity play during aging remain unknown. Here, we present the most comprehensive in vivo study of autophagic flux to date.