Junfeng Li

Nov 4, 2024 | nature.com | Xiaobing Zhai |Abao Xing |Gang Luo |Junfeng Li |Miao Zhou |Cuicui Wang | +7 more

Depression represents a significant global public health challenge, and marital status has been recognized as a potential risk factor. However, previous investigations of this association have primarily focused on Western samples with substantial heterogeneity. Our study aimed to examine the association between marital status and depressive symptoms across countries with diverse cultural backgrounds using a large-scale, two-stage, cross-country analysis. We used nationally representative, de-identified individual-level data from seven countries, including the USA, the UK, Mexico, Ireland, Korea, China and Indonesia (106,556 cross-sectional and 20,865 longitudinal participants), representing approximately 541 million adults. The follow-up duration ranged from 4 to 18 years. Our analysis revealed that unmarried individuals had a higher risk of depressive symptoms than their married counterparts across all countries (pooled odds ratio, 1.86; 95% confidence interval (CI), 1.61–2.14). However, the magnitude of this risk was influenced by country, sex and education level, with greater risk in Western versus Eastern countries (β = 0.36; 95% CI, 0.16–0.56; P < 0.001), among males versus females (β = 0.25; 95% CI, 0.003–0.47; P = 0.047) and among those with higher versus lower educational attainment (β2 = 0.34; 95% CI, 0.11–0.56; P = 0.003). Furthermore, alcohol drinking causally mediated increased later depressive symptom risk among widowed, divorced/separated and single Chinese, Korean and Mexican participants (all P < 0.001). Similarly, smoking was as identified as a causal mediator among single individuals in China and Mexico, and the results remained unchanged in the bootstrap resampling validation and the sensitivity analyses. Our cross-country analysis suggests that unmarried individuals may be at greater risk of depression, and any efforts to mitigate this risk should consider the roles of cultural context, sex, educational attainment and substance use. Analysing data from seven countries, this study found that unmarried individuals had a higher depression risk than married individuals. This risk was higher in Western countries, among males and among those with higher educational attainment.

Nov 27, 2023 | pubs.rsc.org | Junfeng Li |Jia Yu |Haoyang Zou |Jie Zhang

Estrogen receptors-mediated health benefits of phytochemicals: A review Estrogen receptors (ERs) are transcription factors with two subtypes: estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ), which are essential for the maintenance of human health and play a regulatory role in common diseases such as breast cancer, osteoporosis, neurodegenerative disorders, liver injuries and lung cancers.

Sep 30, 2023 | mdpi.com | Ying Liu |dong chen |Junfeng Li |Wei Wang

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticleby 1,*, 2, 1, 1, 1, 1 and 1 1Endocrinology Department, Tianjin First Central Hospital, Nankai University, Tianjin 300192, China2Graduate School, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing100010, China*Author to whom correspondence should be addressed.

Jul 22, 2023 | thelocalw.com | Junfeng Li

The 2023 WNBA All-Star Weekend was a fitting ending to the New York Liberty’s first half of the season. Team Breanna Stewart took down Team A’ja Wilson in the All-Star Game in primetime. The day before, Sabrina Ionescu won the three-point contest with an unprecedented 37-point performance in the final round.

Jun 26, 2023 | pubmed.ncbi.nlm.nih.gov | Junfeng Li |Wenrui Li

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