Kaia Miller

3 weeks ago | nature.com | Molly Thomas |Mari Mino-Kenudson |Kaia Miller |Alexandra-Chloé Villani

AbstractMicroscopic colitis (MC) is a chronic inflammatory disease of the large intestine and a common cause of chronic diarrhea in older adults. Here, we use single-cell RNA sequencing analysis of colonic mucosal tissue to build a cellular and molecular model for MC. Our results show that in MC, there is a substantial expansion of tissue CD8+ T cells, likely arising from local expansion following T cell receptor engagement.