Kaitlin H. Wade

Mar 1, 2024 | bmjmedicine.bmj.com | Nicholas J Timpson |Kaitlin H. Wade |Madeleine Smith |Lucy J. Goudswaard

ConclusionsIn this review, we have invited a reconsideration of how to approach studies exploring the mechanisms of obesity. Focusing on adiposity as well as obesity, we have updated areas of potential mechanistic insight and described the reality of those insights with respect to both cause and consequence. Although assuming that mechanism implies causation might be natural, we argue that mechanisms (or our best measures of them) can be associated with obesity without being causal.

Aug 2, 2023 | onlinelibrary.wiley.com | Kaitlin H. Wade |Nicholas J Timpson |Fergus W Hamilton |Naveed Sattar

TO THE EDITOR: We read with interest the recent letter concerning our self-criticism [(1)] of the nonlinear Mendelian randomization (MR) methodology that we applied in an earlier publication in this journal [(2)].