Nicholas J Timpson

1 month ago | nature.com | Samvida Venkatesh |Duncan Palmer |Nikolas Baya |Melody Parker |Mie T Bruun |Christian Erikstrup | +29 more

AbstractGenome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perform GWAS meta-analyses across seven cohorts in up to 42,629 cases and 740,619 controls and identify 25 genetic risk loci for male and female infertility. We additionally identify up to 269 genetic loci associated with follicle-stimulating hormone, luteinizing hormone, estradiol and testosterone through sex-specific GWAS meta-analyses (n = 6,095–246,862).

Aug 7, 2024 | nature.com | Ahmed Elhakeem |Monika Frysz |Ana Goncalves Soares |Tim Cole |Sylvain Sebert |Kate Tilling | +1 more

AbstractPubertal timing is heritable, varies between individuals, and has implications for life-course health. There are many different indicators of pubertal timing, and how they relate to each other is unclear. Our aim was to quantitatively compare nine indicators of pubertal timing.

Jul 16, 2024 | onlinelibrary.wiley.com | Simon Haworth |Nicholas J Timpson |Kimon Divaris

CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. REFERENCES , , , , , , , & (2024). Complement C3 as a potential drug target in periodontitis: Evidence from the cis-Mendelian randomization approach. Journal of Clinical Periodontology, 51(2), 127–134. https://doi.org/10.1111/jcpe.13894 , , , , , , & (2022). Understanding the consequences of educational inequalities on periodontitis: A Mendelian randomization study.

May 1, 2024 | medrxiv.org | Nicholas J Timpson |Golam M. Khandaker

The authors have declared no competing interest. RSMT is supported by the Tackling Multimorbidity at Scale Strategic Priorities Fund programme (MR/W014416/1) delivered by the Medical Research Council and the National Institute for Health Research in partnership with the Economic and Social Research Council and in collaboration with the Engineering and Physical Sciences Research Council. NJT is the PI of the Avon Longitudinal Study of Parents and Children (MRC & WT 217065/Z/19/Z).

Mar 12, 2024 | nature.com | Nicholas J Timpson

Correction to: Scientific Reports https://doi.org/10.1038/s41598-023-29641-6, published online 17 February 2023The Funding section in the original version of this Article was incomplete. “FH’s time was funded by the GW4-CAT Wellcome Doctoral Fellowship Scheme.”now reads:“FH’s time was funded by the GW4-CAT Wellcome Doctoral Fellowship Scheme (202802/Z/16/Z).”The original Article has been corrected.