Kamyar Hadian

May 16, 2024 | cell.com | Sara Sepic |Annette Gross |Helmholtz Zentrum München |Research Unit-Signaling |Kamyar Hadian |Peter Murray | +5 more

Highlights • Supramolecular WDR26-CTLH E3 complex ubiquitylates oligomeric metabolic enzyme NMNAT1 • WDR26-CTLH E3 recognizes internal basic degron of NMNAT1 through WDR26 β-propellers • Degron mimicry of YPEL5’s N terminus inhibits NMNAT1 targeting by WDR26-CTLH E3 • YPEL5-WDR26-CTLH E3 modulates cellular NMNAT1 amounts affecting its metabolic function Summary The yeast glucose-induced degradation-deficient (GID) E3 ubiquitin ligase forms a suite of complexes with interchangeable receptors...

Aug 7, 2023 | nature.com | Kamyar Hadian |Brent R. Stockwell

AbstractCell death is critical for the development and homeostasis of almost all multicellular organisms. Moreover, its dysregulation leads to diverse disease states. Historically, apoptosis was thought to be the major regulated cell death pathway, whereas necrosis was considered to be an unregulated form of cell death. However, research in recent decades has uncovered several forms of regulated necrosis that are implicated in degenerative diseases, inflammatory conditions and cancer.