-
Sep 1, 2024 | 
nature.com | Juliane Tschuck |Gabriele Ciceri |Jason Tchieu |Brent R. Stockwell |Lorenz Studer |Michael P. Menden | +1 more
AbstractThe development of functional neurons is a complex orchestration of multiple signaling pathways controlling cell proliferation and differentiation. Because the balance of antioxidants is important for neuronal survival and development, we hypothesized that ferroptosis must be suppressed to gain neurons.
-
Jul 15, 2024 | 
medium.com | Brent R. Stockwell
Cindy Cao and Brent R. Stockwell co-authored this article New research has revealed which fats are best, and why. Fish fats such as EPA (short for eicosapentaenoic acid) prevent heart disease.
-
Jun 3, 2024 | 
medium.com | Brent R. Stockwell
A subset of COVID patients experience severe lung damage, leading to fatalities, including 1,901 deaths worldwide over a one-month period ending in mid-May. While many organs are affected by the ever-growing number of variants that cause COVID-19, compromised lung function has been one of the most serious complications since the start of the pandemic in 2020.
-
Mar 20, 2024 | 
nature.com | Zhiming Li |Zhiguo Zhang |Xuejun Jiang |Brent R. Stockwell
AbstractYEATS domain-containing protein GAS41 is a histone reader and oncogene. Here, through genome-wide CRISPR-Cas9 screenings, we identify GAS41 as a repressor of ferroptosis. GAS41 interacts with NRF2 and is critical for NRF2 to activate its targets such as SLC7A11 for modulating ferroptosis. By recognizing the H3K27-acetylation (H3K27-ac) marker, GAS41 is recruited to the SLC7A11 promoter, independent of NRF2 binding.
-
Feb 29, 2024 | 
nature.com | Enyong Dai |Xin McRae Chen |Xuejun Jiang |Rui Kang |Valerian E. Kagan |Ana J. García-Sáez | +27 more
AbstractFerroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity.
-
Jan 8, 2024 | 
medium.com | Brent R. Stockwell
What’s the Difference Between Plant and Animal Protein? Plants and animals look different, but they both contain a lot of protein. And since protein is one of the most crucial nutrients in the foods you eat, you’re wise to understand what it is, how it works, and which kind is best. Bodybuilders think they need it to build muscle. Vegans worry they don’t get enough of it. Many of us are just baffled by it. What is protein, and is there any difference in where it comes from?
-
Nov 8, 2023 | 
medium.com | Brent R. Stockwell
A baby girl died in 1992 when her two-year-old sibling fed her more than 30 glossy red and green tablets. Inside the medicine was the metal iron, deadly when taken in excess. The tablets were intended as a supplement for their mother, but found their way into the children's hands and mouths. Thousands of children are poisoned with iron through such accidents each year, causing tragic deaths. Iron can cause severe damage, but is also essential for health - too much or too little iron impairs health.
-
Sep 25, 2023 | 
medium.com | Brent R. Stockwell
A deadly contaminant stopped thousands of people's hearts, resulting in their deaths, but nobody knew why. Then, in the 1950s, biochemist Fred Kummerow scraped open their arteries and found a lethal fat that had come from their food. As he learned, different fats in our diet are the determinants of health and disease, and control who lives and who doesn't. "It's simple, if it jiggles, it's fat," Arnold Schwarzenegger once said. How wrong he was.
-
Sep 20, 2023 | 
brentstockwell.medium.com | Brent R. Stockwell
The impressive work of Charles Turner, one of first black students to receive a PhD in the U.S., is remembered through a postdoc award in Columbia's Department of Biological Sciences. Charles Turner faced fierce discrimination that severely impacted his ability to do science and have his work appreciated, but nonetheless discovered intelligent hunting behavior of animals a century before it was in vogue in the 1990s.
-
Sep 14, 2023 | 
medium.com | Brent R. Stockwell
This article is part of a Wise & Well Special Report: The United States of Depression. After he was born in 2020, Oliver's doctors told his mother that he had a metabolic disorder that would damage his brain - and later in life, he was at risk for depression. The way depression develops in people with this genetic change - a deficit in specific brain chemicals - reveals much about mood in the wider population.
