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Jan 16, 2025 | 
link.springer.com | Helmholtz Zentrum München
Ensuring the integrity of research data is crucial for the accuracy and reproducibility of any data-based scientific study. This can only be achieved by establishing and implementing strict rules for the handling of research data. Essential steps for achieving high-quality data involve planning what data to gather, collecting it in the correct manner, and processing it in a robust and reproducible way.
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Jan 6, 2025 | 
scitechdaily.com | Helmholtz Zentrum München
Researchers have discovered that the SARS-CoV-2 spike protein persists in the brain and skull bone marrow for years after infection, potentially leading to chronic inflammation and neurodegenerative diseases. Researchers from Helmholtz Munich and Ludwig-Maximilians-Universität (LMU) have uncovered a possible explanation for the neurological symptoms associated with Long COVID.
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Oct 17, 2024 | .html&sz=64)
fis.tu-dresden.de | Kyohsuke Hikino |Technische Universität München |Helmholtz Zentrum München |Jasmin Danzberger
Under ongoing global climate change, drought periods are predicted to increase in frequency and intensity in the future. Under these circumstances, it is crucial for tree's survival to recover their restricted functionalities quickly after drought release. To elucidate the recovery of carbon (C) transport rates in c. 70-year-old Norway spruce (Picea abies [L.] KARST.) after 5 years of recurrent summer droughts, we conducted a continuous whole-tree 13C labeling experiment in parallel with watering.
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Oct 17, 2024 | .html&sz=64)
fis.tu-dresden.de | Technische Universität München |Helmholtz Zentrum München |Kyohsuke Hikino |Jasmin Danzberger
After drought events, tree recovery depends on sufficient carbon (C) allocation to the sink organs. The present study aimed to elucidate dynamics of tree-level C sink activity and allocation of recent photoassimilates (Cnew) and stored C in c. 70-year-old Norway spruce (Picea abies) trees during a 4-week period after drought release. We conducted a continuous, whole-tree 13C labeling in parallel with controlled watering after 5 years of experimental summer drought.
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Sep 26, 2024 | 
bmcmedicine.biomedcentral.com | Helmholtz Zentrum München |Proteomics Core |Heinrich Heine
The present analysis focused on two population-based Cooperative Health Research in the Region of Augsburg (KORA) cohorts for discovery and validation. The inclusion and exclusion criteria are illustrated in Additional file 1: Figure S1. The KORA S4 study enrolled 4261 participants from 1999 to 2001 [21]. The KORA S4 discovery sample used in the present analysis was restricted to those aged 55–74 with available proteomics data (n = 1653).
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Sep 19, 2024 | .html&sz=64)
fis.tu-dresden.de | Chuang Liu |Helmholtz Zentrum München |Ludwig Maximilian |Elaine Fuertes
Negative associations between bone turnover markers and bone mineral density have been reported. In order to study the association between ambient air pollution and bone turnover markers, as indicators of bone loss, we investigated associations between land-use regression modeled air pollution (NO2, PM2.5 mass, PM2.5 - 10 [coarse particles], PM10 mass and PM2.5 absorbance) and bone turnover markers in 2264 children aged 10 years.
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Aug 30, 2024 | 
link.springer.com | Helmholtz Zentrum München
AbstractFor women with locoregionally advanced cervical cancer, the standard of care treatment is the curatively intended chemoradiation therapy (CRT). A relationship between bone marrow (BM) dose–volume histograms (DVHs) and acute hematological toxicity (HT) has been debated recently. Aim of this study was the evaluation of BM dose constraints and HT in a contemporary patient cohort.
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Aug 12, 2024 | 00310-9/fulltext&sz=64)
thelancet.com | Natalia Hernandez-Pacheco |Anna Kilanowski |Helmholtz Zentrum München
SummaryChronic obstructive pulmonary disease (COPD) is caused by interactions between many factors across the life course, including genetics. A proportion of COPD may be due to reduced lung growth in childhood. We hypothesized that a polygenic risk score (PRS) for COPD is associated with lower lung function already in childhood and up to adulthood.
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Aug 9, 2024 | 
bmcmedresmethodol.biomedcentral.com | Helmholtz Zentrum München
ReferencesBauer GR. Sex and gender multidimensionality in Epidemiologic Research. Am J Epidemiol. 2023. https://doi.org/10.1093/aje/kwac173. Article PubMed Google Scholar Bolte G, Jacke K, Groth K, Kraus U, Dandolo L, Fiedel L, et al. Integrating Sex/Gender into Environmental Health Research: development of a conceptual Framework. Int J Environ Res Public Health. 2021. https://doi.org/10.3390/ijerph182212118.
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Aug 1, 2024 | 
jneuroinflammation.biomedcentral.com | Ludwig-Maximilians-Universität München |Bioinformatics Unit |Proteomics Core |Helmholtz Zentrum München
All animal experiments were performed in accordance with the ARVO statement on the use of animals in ophthalmic and vision research and were approved by the local authorities (Regierung von Oberbayern, ROB-55.2-2532.Vet_02-18-143). Mice were kept under standard conditions on a 12 h light/ dark cycle with access to water and food ad libitum. Pde6bSTOP mice were generated in the Barbara & Donald Jonas Stem Cells Laboratory, Columbia University, USA [77].
