Karl F Herold

3 weeks ago | biorxiv.org | David Hollingworth |Karl F Herold |Geoff Kelly |Vitaliy Mykhaylyk

AbstractVoltage-gated sodium channels (VGSCs), key mediators of excitability and synaptic transmission, are established and functionally relevant targets for volatile anaesthetic (VA) action. Using the structurally homologous prokaryotic VGSCs NavMs and NaChBac as models, we present a structure-function analysis of VGSC-VA interactions.

Nov 4, 2024 | biorxiv.org | David Hollingworth |Karl F Herold |Geoff Kelly |Vitaliy Mykhaylyk

AbstractVolatile general anesthetics are used for inhalational anesthesia in hundreds of millions of surgical procedures annually, yet their mechanisms of action remain unclear. Membrane proteins involved in cell signaling are major targets for anesthetics, and voltage-gated ion channels that mediate neurotransmission, movement, and cognition are sensitive to volatile anesthetics (VAs).

Oct 24, 2023 | biorxiv.org | Richard Eastman |Radda Rusinova |Xi-Ping Huang |Karl F Herold

AbstractSince it was proposed as a potential host-directed antiviral agent for SARS-CoV-2, the antiparasitic drug ivermectin has been investigated thoroughly in clinical trials, which have provided insufficient support for its clinical efficacy. To examine the potential for ivermectin to be repurposed as an antiviral agent, we therefore undertook a series of preclinical studies.