Xi-Ping Huang

Aug 4, 2024 | nature.com | Kevin Knight |Brian Krumm |W. Grant Ludlam |Meng Cui |Tyler J. Lefevre |Wenyuan Wei | +9 more

AbstractMany neurotransmitter receptors activate G proteins through exchange of GDP for GTP. The intermediate nucleotide-free state has eluded characterization, due largely to its inherent instability. Here we characterize a G protein variant associated with a rare neurological disorder in humans. GαoK46E has a charge reversal that clashes with the phosphate groups of GDP and GTP.

Oct 24, 2023 | biorxiv.org | Richard Eastman |Radda Rusinova |Xi-Ping Huang |Karl F Herold

AbstractSince it was proposed as a potential host-directed antiviral agent for SARS-CoV-2, the antiparasitic drug ivermectin has been investigated thoroughly in clinical trials, which have provided insufficient support for its clinical efficacy. To examine the potential for ivermectin to be repurposed as an antiviral agent, we therefore undertook a series of preclinical studies.