Karthikeyani Chellappa

Jun 27, 2024 | biorxiv.org | Alice E Kane |Karthikeyani Chellappa |Michael Schultz |Matthew Arnold

AbstractNicotinamide adenine dinucleotide (NAD) is essential for many enzymatic reactions, including those involved in energy metabolism, DNA repair and the activity of sirtuins, a family of defensive deacylases. During aging, levels of NAD+ can decrease by up to 50% in some tissues, the repletion of which provides a range of health benefits in both mice and humans. Whether or not the NAD+ precursor nicotinamide mononucleotide (NMN) extends lifespan in mammals is not known.