Michael Schultz

Nov 7, 2024 | iz.de | Michael Schultz

Sep 5, 2024 | iz.de | Michael Schultz

Jun 27, 2024 | biorxiv.org | Alice E Kane |Karthikeyani Chellappa |Michael Schultz |Matthew Arnold

AbstractNicotinamide adenine dinucleotide (NAD) is essential for many enzymatic reactions, including those involved in energy metabolism, DNA repair and the activity of sirtuins, a family of defensive deacylases. During aging, levels of NAD+ can decrease by up to 50% in some tissues, the repletion of which provides a range of health benefits in both mice and humans. Whether or not the NAD+ precursor nicotinamide mononucleotide (NMN) extends lifespan in mammals is not known.

Sep 19, 2023 | paperity.org | Helen Tang |Chelsea R. Gates |Michael Schultz

PLOS ONE, Aug 2023 Some metabolic enzymes normally occur in the nucleus and cytoplasm. These compartments differ in molecular composition. Since post-translational modification and interaction with allosteric effectors can tune enzyme activity, it follows that the behavior of an enzyme as a catalyst may differ between the cytoplasm and nucleus. We explored this possibility for the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH).

Aug 31, 2023 | journals.plos.org | Helen Tang |Michael Schultz |Chelsea R. Gates

Loading metrics Open Access Peer-reviewedResearch Article Citation: Tang HS, Gates CR, Schultz MC (2023) Biochemical evidence that the whole compartment activity behavior of GAPDH differs between the cytoplasm and nucleus. PLoS ONE 18(8): e0290892. https://doi.org/10.1371/journal.pone.0290892Editor: Prasanth Puthanveetil, Midwestern University, UNITED STATESReceived: June 23, 2023; Accepted: August 15, 2023; Published: August 31, 2023Copyright: © 2023 Tang et al.