Kate Tilling

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Articles

A framework for conducting GWAS using repeated measures data with an application to childhood BMI - Nature Communications

Nov 20, 2024 | nature.com | Kimberley Burrows |Anni Heiskala |Mathilde Boissel |Yee-Ming Chan |Philippe Froguel |Hakon Hakonarson | +8 more

AbstractGenetic effects on changes in human traits over time are understudied and may have important pathophysiological impact. We propose a framework that enables data quality control, implements mixed models to evaluate trajectories of change in traits, and estimates phenotypes to identify age-varying genetic effects in GWAS.
Evaluation and comparison of nine growth and development-based measures of pubertal timing - Communications Medicine

Aug 7, 2024 | nature.com | Ahmed Elhakeem |Monika Frysz |Ana Goncalves Soares |Tim Cole |Sylvain Sebert |Kate Tilling | +1 more

AbstractPubertal timing is heritable, varies between individuals, and has implications for life-course health. There are many different indicators of pubertal timing, and how they relate to each other is unclear. Our aim was to quantitatively compare nine indicators of pubertal timing.

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