Katharina Aigner-Radakovics

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Articles

Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors

Oct 3, 2023 | science.org | Stefan M. Lundgren |Katharina Aigner-Radakovics |Amy Baek |Briana L. Rocha-Gregg

Published In Science SignalingVolume 16 | Issue 805October 2023Article versionsSubmission historyReceived: 27 May 2022Accepted: 23 August 2023PermissionsRequest permissions for this article. AcknowledgmentsWe thank the Flow Cytometry Shared Resource at UC Davis and directors B. McLaughlin and J. Van Dyke for support and guidance. We also thank J. Albeck, M. Burns, M. Huising, and the Collins laboratory members G. Bell, D. Sernas, K. Badu-Nkansah, and E.
The ligand-dependent suppression of TCR signaling by the immune checkpoint receptor LAG3 depends on the cytoplasmic RRFSALE motif

Oct 3, 2023 | science.org | Stefan M. Lundgren |Katharina Aigner-Radakovics |Amy Baek

Published In Science SignalingVolume 16 | Issue 805October 2023Article versionsSubmission historyReceived: 12 December 2022Accepted: 30 August 2023PermissionsRequest permissions for this article. AcknowledgmentsWe are grateful to H.J. Gabius for providing biotinylated Galectin-3. We wish to thank M. Kundi and H. Zipko for statistical consultancy and C. Wenhardt for technical assistance. BioRender.com was used to generate schemes in Figs. 1, 2, 4, and 7.
Stress exhausts T cells

Oct 3, 2023 | science.org | Stefan M. Lundgren |Amy Baek |Katharina Aigner-Radakovics

Editors' ChoiceIMMUNOLOGYT cells are essential for mounting immune responses against infections and cancers but can become exhausted and lose effector function after chronic antigen exposure. Given that T cells express adrenergic receptors and that T cell responses can be affected, at least indirectly, by the sympathetic nervous system, Globig et al. investigated whether adrenergic stress signaling in mice regulates T cells directly.
Stress exhausts T cells

Oct 3, 2023 | sciencemag.org | Stefan M. Lundgren |Katharina Aigner-Radakovics |Amy Baek

Editors' ChoiceIMMUNOLOGYT cells are essential for mounting immune responses against infections and cancers but can become exhausted and lose effector function after chronic antigen exposure. Given that T cells express adrenergic receptors and that T cell responses can be affected, at least indirectly, by the sympathetic nervous system, Globig et al. investigated whether adrenergic stress signaling in mice regulates T cells directly.