Katrina B. Mar

Jul 13, 2023 | nature.com | Katrina B. Mar |Alexandra Wells |Natasha W. Hanners |Bret M. Evers |John M. Shelton

AbstractLY6E is an antiviral restriction factor that inhibits coronavirus spike-mediated fusion, but the cell types in vivo that require LY6E for protection from respiratory coronavirus infection are unknown. Here we used a panel of seven conditional Ly6e knockout mice to define which Ly6e-expressing cells confer control of airway infection by murine coronavirus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).