Bret M. Evers

2 months ago | nature.com | Cyril Pottier |Fahri Küçükali |Matt Baker |Gregory Jenkins |Cristina T. Vicente |Wouter De Coster | +55 more

AbstractFrontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) is a fatal neurodegenerative disorder with only a limited number of risk loci identified.

Dec 20, 2024 | science.org | Robyn Scott |Luiza Tunes |Meng-Hsiung Hsieh |Ping Wang |Ashwani Kumar |Brijesh B Khadgi | +8 more

Published In Science AdvancesVolume 10 | Issue 51December 2024Article versionsSubmission historyReceived: 14 August 2024Accepted: 14 November 2024PermissionsRequest permissions for this article. AcknowledgmentsWe thank O. Koczy, J. Parker, and R. Setlem for contributing to preliminary studies. We are grateful for the helpful discussions with B. Xhemalce on genomic data analysis. The Structural Biology Laboratory at UT Southwestern for help with synchrotron data collection.

Sep 13, 2024 | journalofinfection.com | Isuru A Somawardana |Connor Hunt |Jacob Adams |Tyler Smith |Nicholas Ashton |John Tepper | +10 more

AbbreviationsPJI (Prosthetic joint infections)AMF (Alternating Magnetic Fields)S.

May 14, 2024 | biorxiv.org | Bình Nguyên |Virender Singh |Shumaila Afrin |Bret M. Evers

AbstractATTR amyloidosis is a degenerative disorder characterized by the systemic deposition of the protein transthyretin. These amyloid aggregates of transthyretin (ATTR) can deposit in different parts of the body causing diverse clinical manifestations. Our laboratory aims to investigate a potential relationship between the different genotypes, organ of deposition, clinical phenotypes, and the structure of ATTR fibrils.

May 10, 2024 | biorxiv.org | Yasmin Ahmed |Shumaila Afrin |Virender Singh |Bret M. Evers

AbstractATTR amyloidosis is a phenotypically heterogeneous disease characterized by the pathological deposition of transthyretin in the form of amyloid fibrils into various organs. ATTR amyloidosis may stem from mutations in variant (ATTRv) amyloidosis, or aging in wild-type (ATTRwt) amyloidosis.