Kavya Mathukumalli

Oct 10, 2024 | digitalcommons.library.tmc.edu | Aniket Joshi |Tatiana E. Koike |Anirban Roy |Kavya Mathukumalli

AbstractSkeletal muscle atrophy is a prevalent complication in multiple chronic diseases and disuse conditions. Fibroblast growth factor-inducible 14 (Fn14) is a member of the TNF receptor superfamily and a bona fide receptor of the TWEAK cytokine. Accumulating evidence suggests that Fn14 levels are increased in catabolic conditions as well as during exercise. However, the role of Fn14 in the regulation of skeletal muscle mass and function remains poorly understood.