Tatiana E. Koike

Oct 10, 2024 | digitalcommons.library.tmc.edu | Aniket Joshi |Tatiana E. Koike |Anirban Roy |Kavya Mathukumalli

AbstractSkeletal muscle atrophy is a prevalent complication in multiple chronic diseases and disuse conditions. Fibroblast growth factor-inducible 14 (Fn14) is a member of the TNF receptor superfamily and a bona fide receptor of the TWEAK cytokine. Accumulating evidence suggests that Fn14 levels are increased in catabolic conditions as well as during exercise. However, the role of Fn14 in the regulation of skeletal muscle mass and function remains poorly understood.

Apr 18, 2023 | insight.jci.org | JCI Insight |Anirban Roy |Tatiana E. Koike |Aniket Joshi

AbstractMuscular dystrophies make up a group of genetic neuromuscular disorders that involve severe muscle wasting. TGF-β–activated kinase 1 (TAK1) is an important signaling protein that regulates cell survival, growth, and inflammation. TAK1 has been recently found to promote myofiber growth in the skeletal muscle of adult mice. However, the role of TAK1 in muscle diseases remains poorly understood.