Keenan A. Walker

Jan 13, 2025 | nature.com | Michael Fang |David S. Knopman |Keenan A. Walker |Rebecca Gottesman |Elizabeth Selvin

AbstractUnderstanding the lifetime risk of dementia can inform public health planning and improve patient engagement in prevention. Using data from a community-based, prospective cohort study (n = 15,043; 26.9% Black race, 55.1% women and 30.8% with at least one apolipoprotein E4 (APOE ε4) allele), we estimated the lifetime risk of dementia (from age 55 years to 95 years), with mortality treated as a competing event.

Jun 4, 2024 | nature.com | Andrew Perry |Eric Farber-Eger |Tomas Gonzales |Venkatesh L. Murthy |Laura A. Colangelo |Keenan A. Walker | +8 more

AbstractDespite the wide effects of cardiorespiratory fitness (CRF) on metabolic, cardiovascular, pulmonary and neurological health, challenges in the feasibility and reproducibility of CRF measurements have impeded its use for clinical decision-making. Here we link proteomic profiles to CRF in 14,145 individuals across four international cohorts with diverse CRF ascertainment methods to establish, validate and characterize a proteomic CRF score.

May 22, 2024 | nature.com | Mika Kivimäki |Keenan A. Walker

A study in Nature Aging on electronic health records from 1.7 million people in New Zealand reveals that most patients with dementia have a history of hospital-treated infection. In a dementia-free population, individuals with a severe infection were at a threefold-higher risk of dementia even 25 years later.

Jul 19, 2023 | science.org | Frank Cichocki |Philip Schmassmann |Keenan A. Walker

AbstractA diverse set of biological processes have been implicated in the pathophysiology of Alzheimer’s disease (AD) and related dementias. However, there is limited understanding of the peripheral biological mechanisms relevant in the earliest phases of the disease. Here, we used a large-scale proteomics platform to examine the association of 4877 plasma proteins with 25-year dementia risk in 10,981 middle-aged adults.

Jul 19, 2023 | sciencemag.org | Frank Cichocki |Philip Schmassmann |Keenan A. Walker

AbstractA diverse set of biological processes have been implicated in the pathophysiology of Alzheimer’s disease (AD) and related dementias. However, there is limited understanding of the peripheral biological mechanisms relevant in the earliest phases of the disease. Here, we used a large-scale proteomics platform to examine the association of 4877 plasma proteins with 25-year dementia risk in 10,981 middle-aged adults.