Kelsey Chetnik

Sep 7, 2023 | biorxiv.org | Richa Batra |Rima Kaddurah-Daouk |Annalise Schweickart |Kelsey Chetnik

AbstractRecent advances in high-throughput measurement technologies have enabled the analysis of molecular perturbations associated with disease phenotypes at the multi-omic level. Such perturbations can range in scale from fluctuations of individual molecules to entire biological pathways. Data-driven clustering algorithms have long been used to group interactions into interpretable functional modules; however, these modules are typically constrained to a fixed size or statistical cutoff.