Annalise Schweickart

Sep 5, 2024 | nature.com | Annalise Schweickart |Richa Batra |Rima Kaddurah-Daouk |Anna Halama

AbstractRecent advances in high-throughput measurement technologies have enabled the analysis of molecular perturbations associated with disease phenotypes at the multi-omic level. Such perturbations can range in scale from fluctuations of individual molecules to entire biological pathways. Data-driven clustering algorithms have long been used to group interactions into interpretable functional modules; however, these modules are typically constrained to a fixed size or statistical cutoff.

Jun 11, 2024 | nature.com | Eliah G. Overbey |JangKeun Kim |Braden T. Tierney |Jiwoon Park |Deena Najjar |Remi Klotz | +30 more

AbstractSpaceflight induces molecular, cellular, and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space1-6. Yet, current frameworks for aerospace medicine are nascent and lag far behind advancements in precision medicine on Earth, underscoring the need for rapid development of space medicine databases, tools, and protocols.

Jun 11, 2024 | nature.com | JangKeun Kim |Eliah G. Overbey |Richa Batra |Annalise Schweickart |Deena Najjar |Cem Meydan | +6 more

AbstractAs spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, and extracellular vesicles/particles (EVPs) from the SpaceX Inspiration4 crew, we generated “spaceflight secretome profiles,” which showed significant differences in coagulation, oxidative stress, and brain-enriched proteins.

Jun 10, 2024 | nature.com | Keith Siew |Charlotte Nelson |Alessandra Grillo |Eliah G. Overbey |JangKeun Kim |Sanghee Yun | +41 more

AbstractMissions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.

Jun 10, 2024 | nature.com | Keith Siew |Charlotte Nelson |Alessandra Grillo |Eliah G. Overbey |JangKeun Kim |Sanghee Yun | +41 more

AbstractMissions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.