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3 weeks ago | 
nature.com | Hind Rafei |Rafet Basar |Sunil P Acharya |Vakul Mohanty |Ranjan Upadhyay |Merve Dede | +12 more
AbstractChimeric antigen receptor (CAR) natural killer (NK) cell immunotherapy offers a promising approach against cancer1,2,3. However, the molecular mechanisms that regulate CAR-NK cell activity remain unclear. Here we identify the transcription factor cyclic AMP response element modulator (CREM) as a crucial regulator of NK cell function.
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1 month ago | 
nature.com | Weiqing Chen |Pengzhi Zhang |Keith A. Youker |Li Lai |Longhou Fang |Jun-ichi Abe | +3 more
AbstractArtificial intelligence has revolutionized computational biology. Recent developments in omics technologies, including single-cell RNA sequencing and spatial transcriptomics, provide detailed genomic data alongside tissue histology. However, current computational models focus on either omics or image analysis, lacking their integration.
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2 months ago | 
digitalcommons.library.tmc.edu | Shaoheng Liang |Jinzhuang Dou |Ken Chen |Ramiz Iqbal
AbstractClustering and visualization are essential parts of single-cell gene expression data analysis. The Euclidean distance used in most distance-based methods is not optimal. The batch effect, i.e., the variability among samples gathered from different times, tissues, and patients, introduces large between-group distance and obscures the true identities of cells.
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Nov 21, 2024 | 
digitalcommons.library.tmc.edu | Elaine Stur |Sara Corvigno |Mingchu Xu |Ken Chen
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Nov 20, 2024 | 
msn.com | Ken Chen
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Nov 20, 2024 | 
phys.org | Ken Chen
Stars with masses between 10 and 30 times that of the sun, in their final evolutionary stages, form an iron core that ultimately collapses into a neutron star. This collapse releases a tremendous amount of gravitational potential energy through neutrinos, triggering a shockwave that destroys the entire star.
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Nov 5, 2024 | 
biorxiv.org | Dawei Dai |Ken Chen |Jingwen Tao |Ben Williams
AbstractHow organisms age is a question with broad implications for human health. In mammals, DNA methylation is a biomarker for biological age, which may predict age more accurately than date of birth. However, limitations in mammalian models make it difficult to identify mechanisms underpinning age-related DNA methylation changes.
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Oct 30, 2024 | 
nature.com | Mirazul Islam |Yilin Yang |Alan Simmons |Naila Tasneem |Zhengyi Chen |Iannish D. Sadien | +9 more
AbstractTemporal ordering of cellular events offers fundamental insights into biological phenomena. Although this is traditionally achieved through continuous direct observations1,2, an alternative solution leverages irreversible genetic changes, such as naturally occurring mutations, to create indelible marks that enables retrospective temporal ordering3,4,5.
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Oct 24, 2024 | 
medrxiv.org | Ken Chen |Ying Zhao |Zheng Wei |Ying Yu
The authors have declared no competing interest. The present study is a Mendelian Randomization study, thus we did not have a clinical trial ID. No external funding was received. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
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Sep 11, 2024 | 
mdpi.com | Zisheng Li |Ken Chen |Yaoqin Xie
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
