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1 month ago | 
physoc.onlinelibrary.wiley.com | Michael Maxwell |Ben Murphy |Fiona McDonald |Ken D. O'Halloran
1 INTRODUCTION Duchenne muscular dystrophy (DMD) is a life-limiting X-linked neuromuscular disease arising from mutations in the DMD gene, leading to the absence of the structural protein dystrophin (Aartsma-Rus et al., 2006; Hoffman et al., 1987).
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Dec 6, 2024 | 
physoc.onlinelibrary.wiley.com | Ken D. O'Halloran
The diaphragm is the primary muscle of inspiration. Diaphragm dysfunction is surprisingly common, presenting in acute critical care, cardiorespiratory diseases, cancer cachexia, endocrine disorders, and neuromuscular and neurodegenerative diseases amongst other scenarios (Laghi et al., 2021).
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Aug 6, 2024 | 
physoc.onlinelibrary.wiley.com | Ken D. O'Halloran
More than 60 years ago, the principles of the 3Rs (replacement, reduction and refinement) were crystalised by Russell and Burch (1959), providing an ethical framework for the conduct of scientific enquiry in laboratory animals. Today, the 3Rs are a centrepiece of legislation concerning the protection of animals used for scientific purposes.
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Jul 18, 2024 | 
physoc.onlinelibrary.wiley.com | Rebecca Delaney |Ken D. O'Halloran
1 DUCHENNE MUSCULAR DYSTROPHY Duchenne muscular dystrophy (DMD) is a fatal X-linked neuromuscular disease. It is characterized by a complete absence of the 427 kDa protein, dystrophin. Dystrophin is localized at the sarcolemma of skeletal and cardiac muscle (Figure 1). It plays a role in maintaining muscle integrity during repeated oscillations of contraction and relaxation (Wong et al., 2020).
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Jun 26, 2024 | 
physoc.onlinelibrary.wiley.com | Ken D. O'Halloran
Relatively recently, was approached by media outlets to comment on mouth taping. With no social media presence and no interest in it, I was blissfully unaware of the ‘hack’ that purportedly improves all manner of things. This topic, now ‘viral’, has also cropped up, repeatedly, on mainstream media platforms worldwide.
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Jun 4, 2024 | 
physoc.onlinelibrary.wiley.com | Ken D. O'Halloran
Breathing is essential to life. It facilitates cyclical ventilation of the pulmonary alveoli to maintain homeostatic levels of oxygen (O2) and carbon dioxide (CO2) in the blood, matching the metabolic requirements of the body (Fig. 1).
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Apr 17, 2024 | 
physoc.onlinelibrary.wiley.com | Ken D. O'Halloran
This editorial is intended to highlight key reporting obligations pertaining to ethics and animal welfare matters for papers published in The Journal of Physiology. On occasion, research articles under consideration at The Journal are referred to me for review of ethics and welfare issues. I also have sight of many more articles in the context of my contribution as a Reviewing Editor.
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Dec 5, 2023 | 
physoc.onlinelibrary.wiley.com | Ken D. O'Halloran
Neuromuscular activation of striated muscles of the upper airway is critical to the control of pharyngeal airway patency. In obstructive sleep apnoea (OSA), a common sleep-related breathing disorder, periodic occlusions of the upper airway interrupt pulmonary ventilation resulting in repeated exposures to hypoxia, which is recognised to drive multisystem morbidity.
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Oct 12, 2023 | 
physoc.onlinelibrary.wiley.com | Ken D. O'Halloran
The marriage of breath and beat is critical for life. Cardiorespiratory integration greatly facilitates the capacity to meet metabolic demand in skeletal muscle during active work across a broad range of exercise intensities. The union is established in brainstem sites providing the neural substrate for cardiorespiratory signatures transmitted in physiological counterpoint to the periphery and is most evident in the anatomical coupling of the heart and respiratory structures in the thorax.
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Sep 18, 2023 | 
physoc.onlinelibrary.wiley.com | Ken D. O'Halloran
It has been established that the respiratory control network responsible for the regulation of arterial blood gases and other aspects of respiratory performance is amenable to considerable plasticity, both in health and in disease.
