Kevin J. Mao

Jan 15, 2025 | cell.com | Qi Wen Teo |Yiquan Wang |Huibin Lv |Michael S. Oade |Kevin J. Mao |Timothy J.C. Tan | +8 more

Keywordsinfluenza virusNS1nuclear export proteinNEPevolutionary constraintsthe transcription-to-replication switchinnate immune responsecellular apoptosismammalian adaptation of avian influenza virusResearch topic(s)CP: MicrobiologyCP: Molecular biologyIntroductionInfluenza A virus (IAV) belongs to the Orthomyxoviridae family and is characterized as an enveloped, negative-sense, single-stranded, segmented RNA virus.

May 18, 2024 | biorxiv.org | Qi Wen Teo |Yiquan Wang |Huibin Lv |Kevin J. Mao

AbstractThe influenza A virus nuclear export protein (NEP) is a multifunctional protein that is essential for the viral life cycle and has very high sequence conservation. However, since the open reading frame of NEP largely overlaps with that of another influenza viral protein, non-structural protein 1, it is difficult to infer the functional constraints of NEP based on sequence conservation analysis.