Timothy J.C. Tan

Jan 15, 2025 | cell.com | Qi Wen Teo |Yiquan Wang |Huibin Lv |Michael S. Oade |Kevin J. Mao |Timothy J.C. Tan | +8 more

Keywordsinfluenza virusNS1nuclear export proteinNEPevolutionary constraintsthe transcription-to-replication switchinnate immune responsecellular apoptosismammalian adaptation of avian influenza virusResearch topic(s)CP: MicrobiologyCP: Molecular biologyIntroductionInfluenza A virus (IAV) belongs to the Orthomyxoviridae family and is characterized as an enveloped, negative-sense, single-stranded, segmented RNA virus.

Nov 15, 2023 | cell.com | Qi Wen Teo |Yiquan Wang |Huibin Lv |Timothy J.C. Tan

Highlights•Compatibilities of CR9114 with diverse light chains and CDR H3s are probed•Light chain of CR9114, despite having no contact with the epitope, is important for binding•Most CDR H3s from other IGHV1-69 HA stem antibodies are incompatible with CR9114SummaryIGHV1-69 is frequently utilized by broadly neutralizing influenza antibodies to the hemagglutinin (HA) stem. These IGHV1-69 HA stem antibodies have diverse complementarity-determining region (CDR) H3 sequences.

Jul 6, 2023 | biorxiv.org | Yiquan Wang |Timothy J.C. Tan |Qi Wen Teo |Huibin Lyu

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