Yiquan Wang

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Articles

Probing the functional constraints of influenza A virus NEP by deep mutational scanning

Jan 15, 2025 | cell.com | Qi Wen Teo |Yiquan Wang |Huibin Lv |Michael S. Oade |Kevin J. Mao |Timothy J.C. Tan | +8 more

Keywordsinfluenza virusNS1nuclear export proteinNEPevolutionary constraintsthe transcription-to-replication switchinnate immune responsecellular apoptosismammalian adaptation of avian influenza virusResearch topic(s)CP: MicrobiologyCP: Molecular biologyIntroductionInfluenza A virus (IAV) belongs to the Orthomyxoviridae family and is characterized as an enveloped, negative-sense, single-stranded, segmented RNA virus.
Deficiency of histamine H2 receptors in parvalbumin-positive neurons leads to hyperactivity, impulsivity, and impaired attention

Jan 8, 2025 | cell.com | Dadao An |Yi You |Qianyi Ma |Zhengyi Xu |Zonghan Liu |Ruichu Liao | +8 more

Keywordshistamine H2 receptorattention deficit hyperactivity disordersubstantia nigra pars reticulataparvalbumin-positive neuronsubstantia nigra pars compactaintermediate layers of superior colliculushistaminedopaminergic neuronsGet full text accessLog in, subscribe or purchase for full access. References1. Biederman, J. Attention-deficit/hyperactivity disorder: a selective overviewBiol. Psychiatry. 2005; 57:1215-12202. Thapar, A. ∙ Cooper, M. Attention deficit hyperactivity disorderLancet.
Multi-UAV Path Planning for Air-Ground Relay Communication Based on Mix-Greedy MAPPO Algorithm

Nov 26, 2024 | mdpi.com | Yiquan Wang |Yan Cui |Yu Yang |Zhaodong Li

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Octopus Inspired Optimization Algorithm: Multi-Level Structures and Parallel Computing Strategies

Oct 10, 2024 | arxiv.org | Longji Xu |Yiquan Wang |Yuhua Dong |Xiang Li
Deep mutational scanning of influenza A virus NEP reveals pleiotropic mutations in its N-terminal domain

May 18, 2024 | biorxiv.org | Qi Wen Teo |Yiquan Wang |Huibin Lv |Kevin J. Mao

AbstractThe influenza A virus nuclear export protein (NEP) is a multifunctional protein that is essential for the viral life cycle and has very high sequence conservation. However, since the open reading frame of NEP largely overlaps with that of another influenza viral protein, non-structural protein 1, it is difficult to infer the functional constraints of NEP based on sequence conservation analysis.
Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem

Nov 15, 2023 | cell.com | Qi Wen Teo |Yiquan Wang |Huibin Lv |Timothy J.C. Tan

Highlights•Compatibilities of CR9114 with diverse light chains and CDR H3s are probed•Light chain of CR9114, despite having no contact with the epitope, is important for binding•Most CDR H3s from other IGHV1-69 HA stem antibodies are incompatible with CR9114SummaryIGHV1-69 is frequently utilized by broadly neutralizing influenza antibodies to the hemagglutinin (HA) stem. These IGHV1-69 HA stem antibodies have diverse complementarity-determining region (CDR) H3 sequences.
An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies

Sep 14, 2023 | biorxiv.org | Yiquan Wang |Huibin Lv |Ruipeng Lei |Yuen-Hei Yeung

AbstractDespite decades of antibody research, it remains challenging to predict the specificity of an antibody solely based on its sequence. Two major obstacles are the lack of appropriate models and inaccessibility of datasets for model training. In this study, we curated a dataset of >5,000 influenza hemagglutinin (HA) antibodies by mining research publications and patents, which revealed many distinct sequence features between antibodies to HA head and stem domains.
Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem

Jul 6, 2023 | biorxiv.org | Yiquan Wang |Timothy J.C. Tan |Qi Wen Teo |Huibin Lyu

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Yiquan Wang

Articles

Probing the functional constraints of influenza A virus NEP by deep mutational scanning

Deficiency of histamine H2 receptors in parvalbumin-positive neurons leads to hyperactivity, impulsivity, and impaired attention

Multi-UAV Path Planning for Air-Ground Relay Communication Based on Mix-Greedy MAPPO Algorithm

Octopus Inspired Optimization Algorithm: Multi-Level Structures and Parallel Computing Strategies

Deep mutational scanning of influenza A virus NEP reveals pleiotropic mutations in its N-terminal domain

Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem

An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies

Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem

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Emails

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