Kexin Lin

Jun 5, 2024 | cell.com | Shiyu Li |Hui Shen |Xuehui Lyu |Kexin Lin

The cleavage of zygotes generates totipotent blastomeres. In human 8-cell blastomeres, zygotic genome activation (ZGA) occurs to initiate the ontogenesis program. However, capturing and maintaining totipotency in human cells pose significant challenges. Here, we realize culturing human totipotent blastomere-like cells (hTBLCs).